Ganoderma Spore

The Mechanism of Anti-Cancer Effects of Sporin 

  NAHA's Spore King^TM  

~Alternative medicine/supplement for Cancer~

What is Ganoderma?

• To be a supplement in chemotherapy and radiotherapy to help reduce the side effects, such as fatigue, loss of appetite, hair loss, bone marrow suppression and risk of infection;
• To be a supplement for cancer patients to improve survival and reduce the likelihood of metastasis;
• To be a supplement for cancer patients to improve their quality of life. Oral glucan derivatives, such as PSP, have been found to decrease pain;
• To be a supplement for the prevention of cancer. Many years of research have shown that immune stimulation, including Natural Killer (NK) cells and Cytotoxic Lymphocyte (CTL), are effective in cancer prevention by enhancing the immune system. Ganoderma, especially Ganoderma spore, has been demonstrated to enhance NK and CTL activity when administered orally. Ganoderma spore is a good candidate for the prevention of and recurrence of cancer.

The Mechanism of Anti-Cancer Effects of Sporin from Glossy Ganoderma

1. Growth and Metastasis of Tumors

Connected to the primary tumors, the bloodstreams provide to tumors not only oxygen and nutrition, but also the invading route. After breaking loose from tumors, the cancer cells enter the circulation system and may settle down in sites far from the primary tumors and form secondary tumors.

Clinical observations have confirmed that it is the secondary tumors (also called satellite tumors) that present real threat to the patients, while the primary tumors can secrete certain inhibitor that block the growth of the secondary tumors. 

Cancer treatments are aimed to control and eliminate cancer foci, maintain and restore patients’ overall physiological function, and achieve a complete recovery to the end. Tumor surgeries, which are mainly to remove local focus physically, are mostly applied for palliative resection on patients at early or pre-advanced stage. For patients at advanced stage or with a weak constitution with metastasis or re-occurrence, they may not be strong enough to stand an operation and conservative treatments are much more preferred. Chemotherapy has been shown to be effective against several types of cancers, but in most cases it was used as a supplementary treatment. Moreover, due to its severe side effect, symptoms such as thirst, alopecia, nausea, vomit, debility, liver malfunction and leukocytopenia often occurred, which stop the patients from further treatment. Radiotherapy is used against local remote metastasis, or metastasis of remnant cancer cells after other treatments, and can cause side effects similar to that by chemotherapy. Other treatments, such as chemotherapy, cold therapy, laser, intervention, and immunotherapy, which are getting more and more popular, are also bound with limitation and disadvantage. 

In the process of cancer treatment, a large portion of patients died not of cancers, but of impropriate treatments. If aggressive methods, such as surgery, radiotherapy, chemotherapy, or intervention, are always chosen as the first option of treatment, patients who themselves have only weak resistance against disease may die of wound infection or anastomotic leakage. On the other hand, if during the treatment Chinese medicine can be applied as supplement, following the philosophy of “asthenis induces illness” and “illness causes asthenis” in cancer therapy and keeping an eye on the balance of main and collateral channels, the disadvantage of surgery, chemotherapy and radiotherapy may be remedied, their effect be enhanced, and their toxic side effect be decreased. For patients at early stage, removal of cancer foci is the prior goal and surgery should be arranged at early convenience; for patients at middle stage, attentions are to be paid to both focus removal as well as constitution improvement; for patients with advanced cancer, however, due to their very undermined constitution and weak resistance to disease, treatments should focus on enhancing their constitution and, only after their general situations are improved, appropriate treatment may be considered accordingly to eliminate the cancer foci. 

After the primary tumors are removed by surgery, the inhibitory effect of the primary tumors disappears and the tiny secondary tumors become active, (like pupils in their classroom after their teacher leaves,) and they rapidly grow and bring about the eventual fate of the patients. 

Therefore, the core of cancer treatment is to learn how to control the growth rate of the primary tumors and block the cancer cells, so metastasis can be prevented and cancer be induced to gradual death. 

2. The Mechanism of the activity of Sporin from Glossy Ganoderma

Mechanism I: to destroy telomerase and inhibit cancer 

Sporin from Glossy Ganoderma has showed remarked effect in clinic for curing cancers. Extensive pharmacological tests confirmed, and it is also widely recognized, that Sporin from Glossy Ganoderma is today’s most effective Chinese medical preparation for cancer prevention and cure. And it has paved a new route to our eventual victory over cancers. 

Why does the extract from Glossy Ganoderma have anti-cancer activity? The conclusion can be easily reached if we look into the difference in growth of cancer and normal cells. The normal human cells have defined life span, and cells of old generation will die out automatically when new generation of cells duplicate and get matured. This cycle of cell proliferation ensures the ordinary physiology of human organs. The cancer cells, on the other hand, are mutated cells that reproduce themselves without restrain and possess a strong vitality and do not get to aging. Growth of cancer cells impedes that of the normal organ cells, leading the latter to malfunction. Recent research has revealed that cancer cells contain a “longevous” enzyme, known as telomerase. In normal cells as well as in cancer cells, there is a segment of DNA on the chromosome ends (called telomere) that endows the parent cells and their offspring cells with the same hereditary characteristics. Nevertheless, in normal cells the telomeres becomes shortened after each cycle of cell division, and after certain number of division cycles, the telomeres will be all gone and the cells will not be able to divide any further. Then the cells will gradually age and die eventually. The telomerase in cancer cells, however, is able to not only prevent telomeres from getting shortened during the cell division, but also replace them, thus contributing to the unlimited dividing potent of cancer cells. 

By now about 100 cultures of cancer cells have been tested and 98 of them are found to contain telomerase. Besides, of 101 in vivo samples from 12 types of different cancers, 90 showed positive results. On the contrast, none of 22 lines of cultured normal cells are found to contain telomerase. 

So how to block and destroy the telomerase in cancer cells so that the cancer cells will also become aged and die after cycles of cell division? Clinical trials showed that Sporin from Glossy Ganoderma has the capacity to destroy the telomerase in cancer cells as well as to block the enzyme activity, thereby inducing cancer cells to aging and curing the cancers. In in vitro experiments with cultures of cancer cells, Sporin from Glossy Ganoderma showed a 100% rate in destroying telomerase in cancer cells, and 83.3% in inhibiting cancer metastasis, and it helps many advanced cancer patients to a complete recovery. 

Mechanism II: to induce interferon and kill cancer cells 

The physiologically active components in Sporin from Glossy Ganoderma are able to directly stimulate the proliferation of lymphocytes, induce the production of interleukin-2 and onconecrotic factor, enhance the engulf capacity of macrophage, increase the activity of natural killer cells, improve the function of reticuloendothelial system, and inhibit the growth and spread of cancer cells.  While stimulating the immunological competence of human body, they also activate thymus to produce T- and B-lymphocytes, inhibit the cancer growth, induce the production of α- and β-interferon and immunoglobulins, and increase the resistance to many diseases. 

The immunological anti-cancer mechanism of Sporin from Glossy Ganoderma has been confirmed by clinic and experiments. It not only enhances human immunological system, but also strengthens each step of the immunoreactions. It also causes no damage to normal human cells while destroying cancer cells. There are studies showing that cancer cells can be destroyed only when the immunological competence of the patient is above certain level, but unfortunately many immunopotentiators are not able to achieve this goal. 

Pharmacological Analysis of Active Components in Sporin from Glossy Ganoderma

             Extensive experiments and clinical trials conducted in China and many other countries have confirmed that, among the active components of Sporin from Glossy Ganoderma, polysaccharides, organic germanic compounds, and triterpenoides have characteristic effects in destroying telomerase in cancer cells and inhibiting and killing the malignant cells. 

1. Polysaccharides of Glossy Ganoderma 

        This component can remarkably increase the human immunoreactions.  By activating thymus to produce T- and B-lymphocytes, it increase the activity of human natural killing cell. It also stimulates macrophages to produce hemopoietic stimulator, which can be transported to other parts of human body through the circulation system and supplement the vitality damaged by cancer cells, thereby increasing the organic resistance to cancer and indirectly helping killing the cancer cells. At the same time, the activated lymphocytes execute their activity around cancer cells and produce large amount of stimulating factors that can destroy the telomerase activity in cancer cells and promote engulf capacity, thus directly killing cancer cells. 

2. Triterpenoides                         

           This component can inhibit cancer metastasis and decrease the oncogenic chance of chemical and viral oncogenesis. It also remarkably decreases the toxic side effect arisen from cancer drugs and rapidly diminishes various types of ascots caused by cancers. 

3. Nucleic Acid Compounds (G Lucidum, G capense, G applaneum) 

          This group of compounds, including adenine, adenosine, and uridine nucleotide, can effectively inhibit thrombocyte coagulation and induce the production of interferon, and induce analgesis and sedation. 

4. Organic Germanic compounds (Ge)     

           This component is able to adjust the changed organic electric potential caused by cancer growth and resumes it to the optimal state. At the same time it destructs the condition for cancer growth, thus effectively relieving pains caused by cancers. 

To sum up, Sporin from Glossy Ganoderma contains many pharmacologically active components that can function to resist radiation damage, relieve the side effect from radiotherapy and chemotherapy, rapidly increase the number of leukocytes, enhance organic immunofunction, and inhibit growth and metastasis of cancer cells. Moreover, the cuticle in the sporo-pollen also shows the activity of restoring normal cells after the cancer cells are killed. 

The Mechanism of Anti-Cancer Effects of Sporin from Glossy Ganoderma 

1. Growth and Metastasis of Tumors

Connected to the primary tumors, the bloodstreams provide to tumors not only oxygen and nutrition, but also the invading route. After breaking loose from tumors, the cancer cells enter the circulation system and may settle down in sites far from the primary tumors and form secondary tumors. 

Clinical observations have confirmed that it is the secondary tumors (also called satellite tumors) that present real threat to the patients, while the primary tumors can secrete certain inhibitor that block the growth of the secondary tumors. 

Cancer treatments are aimed to control and eliminate cancer foci, maintain and restore patients’ overall physiological function, and achieve a complete recovery to the end. Tumor surgeries, which are mainly to remove local focus physically, are mostly applied for palliative resection on patients at early or pre-advanced stage. For patients at advanced stage or with a weak constitution with metastasis or re-occurrence, they may not be strong enough to stand an operation and conservative treatments are much more preferred. Chemotherapy has been shown to be effective against several types of cancers, but in most cases it was used as a supplementary treatment. Moreover, due to its severe side effect, symptoms such as thirst, alopecia, nausea, vomit, debility, liver malfunction and leukocytopenia often occurred, which stop the patients from further treatment. Radiotherapy is used against local remote metastasis, or metastasis of remnant cancer cells after other treatments, and can cause side effects similar to that by chemotherapy. Other treatments, such as chemotherapy, cold therapy, laser, intervention, and immunotherapy, which are getting more and more popular, are also bound with limitation and disadvantage. 

In the process of cancer treatment, a large portion of patients died not of cancers, but of impropriate treatments. If aggressive methods, such as surgery, radiotherapy, chemotherapy, or intervention, are always chosen as the first option of treatment, patients who themselves have only weak resistance against disease may die of wound infection or anastomotic leakage. On the other hand, if during the treatment Chinese medicine can be applied as supplement, following the philosophy of “asthenis induces illness” and “illness causes asthenis” in cancer therapy and keeping an eye on the balance of main and collateral channels, the disadvantage of surgery, chemotherapy and radiotherapy may be remedied, their effect be enhanced, and their toxic side effect be decreased. For patients at early stage, removal of cancer foci is the prior goal and surgery should be arranged at early convenience; for patients at middle stage, attentions are to be paid to both focus removal as well as constitution improvement; for patients with advanced cancer, however, due to their very undermined constitution and weak resistance to disease, treatments should focus on enhancing their constitution and, only after their general situations are improved, appropriate treatment may be considered accordingly to eliminate the cancer foci. 

After the primary tumors are removed by surgery, the inhibitory effect of the primary tumors disappears and the tiny secondary tumors become active, (like pupils in their classroom after their teacher leaves,) and they rapidly grow and bring about the eventual fate of the patients. 

Therefore, the core of cancer treatment is to learn how to control the growth rate of the primary tumors and block the cancer cells, so metastasis can be prevented and cancer be induced to gradual death. 

2. The Mechanism of the activity of Sporin from Glossy Ganoderma

Mechanism I: to destroy telomerase and inhibit cancer

Sporin from Glossy Ganoderma has showed remarked effect in clinic for curing cancers. Extensive pharmacological tests confirmed, and it is also widely recognized, that Sporin from Glossy Ganoderma is today’s most effective Chinese medical preparation for cancer prevention and cure. And it has paved a new route to our eventual victory over cancers.

         Why does the extract from Glossy Ganoderma have anti-cancer activity? The conclusion can be easily reached if we look into the difference in growth of cancer and normal cells. The normal human cells have defined life span, and cells of old generation will die out automatically when new generation of cells duplicate and get matured. This cycle of cell proliferation ensures the ordinary physiology of human organs. The cancer cells, on the other hand, are mutated cells that reproduce themselves without restrain and possess a strong vitality and do not get to aging. Growth of cancer cells impedes that of the normal organ cells, leading the latter to malfunction. Recent research has revealed that cancer cells contain a “longevous” enzyme, known as telomerase. In normal cells as well as in cancer cells, there is a segment of DNA on the chromosome ends (called telomere) that endows the parent cells and their offspring cells with the same hereditary characteristics. Nevertheless, in normal cells the telomeres becomes shortened after each cycle of cell division, and after certain number of division cycles, the telomeres will be all gone and the cells will not be able to divide any further. Then the cells will gradually age and die eventually. The telomerase in cancer cells, however, is able to not only prevent telomeres from getting shortened during the cell division, but also replace them, thus contributing to the unlimited dividing potent of cancer cells.

         By now about 100 cultures of cancer cells have been tested and 98 of them are found to contain telomerase. Besides, of 101 in vivo samples from 12 types of different cancers, 90 showed positive results. On the contrast, none of 22 lines of cultured normal cells are found to contain telomerase.

        So how to block and destroy the telomerase in cancer cells so that the cancer cells will also become aged and die after cycles of cell division? Clinical trials showed that Sporin from Glossy Ganoderma has the capacity to destroy the telomerase in cancer cells as well as to block the enzyme activity, thereby inducing cancer cells to aging and curing the cancers. In in vitro experiments with cultures of cancer cells, Sporin from Glossy Ganoderma showed a 100% rate in destroying telomerase in cancer cells, and 83.3% in inhibiting cancer metastasis, and it helps many advanced cancer patients to a complete recovery.

Mechanism II: to induce interferon and kill cancer cells

The physiologically active components in Sporin from Glossy Ganoderma are able to directly stimulate the proliferation of lymphocytes, induce the production of interleukin-2 and onconecrotic factor, enhance the engulf capacity of macrophage, increase the activity of natural killer cells, improve the function of reticuloendothelial system, and inhibit the growth and spread of cancer cells.  While stimulating the immunological competence of human body, they also activate thymus to produce T- and B-lymphocytes, inhibit the cancer growth, induce the production of α- and β-interferon and immunoglobulins, and increase the resistance to many diseases. 

The immunological anti-cancer mechanism of Sporin from Glossy Ganoderma has been confirmed by clinic and experiments. It not only enhances human immunological system, but also strengthens each step of the immunoreactions. It also causes no damage to normal human cells while destroying cancer cells. There are studies showing that cancer cells can be destroyed only when the immunological competence of the patient is above certain level, but unfortunately many immunopotentiators are not able to achieve this goal. 

Pharmacological Analysis of Active Components in Sporin  from Glossy Ganoderma 

          Extensive experiments and clinical trials conducted in China and many other countries have confirmed that, among the active components of Sporin from Glossy Ganoderma, polysaccharides, organic germanic compounds, and triterpenoides have characteristic effects in destroying telomerase in cancer cells and inhibiting and killing the malignant cells. 

1. Polysaccharides of Glossy Ganoderma 

         This component can remarkably increase the human immunoreactions.  By activating thymus to produce T- and B-lymphocytes, it increase the activity of human natural killing cell. It also stimulates macrophages to produce hemopoietic stimulator, which can be transported to other parts of human body through the circulation system and supplement the vitality damaged by cancer cells, thereby increasing the organic resistance to cancer and indirectly helping killing the cancer cells. At the same time, the activated lymphocytes execute their activity around cancer cells and produce large amount of stimulating factors that can destroy the telomerase activity in cancer cells and promote engulf capacity, thus directly killing cancer cells. 

2. Triterpenoides                         

       This component can inhibit cancer metastasis and decrease the oncogenic chance of chemical and viral oncogenesis. It also remarkably decreases the toxic side effect arisen from cancer drugs and rapidly diminishes various types of ascots caused by cancers. 

3. Nucleic Acid Compounds (G Lucidum, G capense, G applaneum) 

      This group of compounds, including adenine, adenosine, and uridine nucleotide, can effectively inhibit thrombocyte coagulation and induce the production of interferon, and induce analgesis and sedation. 

4. Organic Germanic compounds (Ge)     

         This component is able to adjust the changed organic electric potential caused by cancer growth and resumes it to the optimal state. At the same time it destructs the condition for cancer growth, thus effectively relieving pains caused by cancers. 

To sum up, Sporin from Glossy Ganoderma contains many pharmacologically active components that can function to resist radiation damage, relieve the side effect from radiotherapy and chemotherapy, rapidly increase the number of leukocytes, enhance organic immunofunction, and inhibit growth and metastasis of cancer cells. Moreover, the cuticle in the sporo-pollen also shows the activity of restoring normal cells after the cancer cells are killed.

Contact information

Tel: 909-396-8732
Fax: 909-396-8765

nahaent@verizon.net

 

 

 

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Last updated June 6, 2003

These statements have not been evaluated by FDA. The products are not intended to diagnose, treat, cure or prevent any diseases